Senator Jeff Flake (R-AZ) will not seek reelection when his term expires in 2018, citing disagreement with the direction of his party and the overall polarized political climate. Read the full article here, which includes a video of the floor remarks in which he makes this announcement. A transcript of his full remarks, which have been widely discussed, is available here. His race will be of interest because while it will be mostly Democratic Senators defending their seats that year, the GOP controls the Senate by a slim margin of 52 seats.
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